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A dating app that’s changing the match game, meet “Giggles”- a safe, soulful resolution in modern connections.

A dating app that’s changing the match game, meet “Giggles”- a safe, soulful resolution in modern connections.

Giggles is redefining the industry with its “safety first” approach, similar to the famous “women’s first approach” back in 2018.

Backed by a new wave of investor interests- the most anticipated dating app of this era is gearing for its country wide launch focusing on safety as foundation and not just a feature. Born in India, meticulously built for the world- setting an example, Giggles Platonic Dating is more than just an App- it’s a bold experiment in safe dating, committing physical help with a network of ground support teams stationed across the city, deployed in case of discomfort during in-person meets.

Following a pre-seed angel investment of $300k early August, gaining goodwill with the conceptualized USPs such as: Aadhar based face verification, gender-balanced access via an active waitlist system with an engaging waitlist experience, time sensitive matches, vibrant combination of social media and dating app with features like post, snips and swipes, and SoS ground support, are some of the major promises. However, the growth or fall, survival and sustainability depend on the operational efficiency of the core team, as the promising ground support comes with extensive operational complexity.

India is projected to be the second largest industry for dating in the world, but the lack of security and safe dating practices among the masses is a serious concern. While Giggles wants to deliver a safety-first dating experience in India for the first time ever, many have manifested this concept in the past, but backed-out due to the last mile delivery operational complexities of the promised services.

Dating apps are often short-lived, making a quick revenue before they are lost among 100 or more similar apps in the same niche. USPs can be copied, UI and UX can be remade and the overall user experience can be bettered with better hires, but the ultimate decider is the operational model– at least for Giggles’ ground network supported business model.

The “Giggles Platonic Dating” application is now officially available for user downloads on both android and iOS platforms.

Shivaami Named A Google Cloud Partner of the Year!

Shivaami Named A Google Cloud Partner of the Year!

Powering 20,000+ Businesses with Google Workspace Excellence

Shivaami, a trailblazer in cloud solutions, has been crowned “Google Workspace Partner of the Year for Asia Pacific” for Google Workspace sales, support, and change management!  This prestigious recognition is validation to Shivaami’s work in cloud transformation, empowering over 20,000 businesses to work smarter, collaborate seamlessly, and scale faster.

“Google Cloud’s Partner Awards recognize partners who have created outsized value for customers through the delivery of innovative solutions and a high level of expertise,” said Kevin Ichhpurani, President, Global Partner Ecosystem, Google Cloud. “We’re proud to announce Shivaami as a 2025 Google Cloud Partner Award winner and celebrate their impact enabling customer success over the past year.”

What Makes Shivaami Stand Out?

  • A Cloud Partner That Delivers: With 250+ Google Cloud-certified experts, Shivaami doesn’t just sell Google Workspace—it helps to revolutionize the way businesses work! From small startups to global enterprises, our tailored solutions help companies boost efficiency, security, and innovation.
  • Lightning-Fast Support: We’ve raised the bar with 24×7 customer support, responding to 90% of tickets within 4 minutes and resolving them within 40 minutes. No long waits—just instant solutions!
  • Empowering Digital Transformation: Whether it’s cloud security, application modernization, or infrastructure transformation, Shivaami is helping companies move to the cloud with confidence and agility.
  • Award-Winning Partner 6 Years in a Row: Our winning streak as a Google Cloud Partner of the Year speaks volumes about our commitment to excellence and customer success.
  • Championing Women in Tech: We’re proud to have 80% of our workforce made up of women, leading the charge in cloud innovation.

A Message from Our CEO, Punit Thakkar
“Winning this award is a testament to the passion and expertise of our team. At Shivaami, our mission is to transform lives through cloud technology, making businesses more efficient, secure, and future-ready. This recognition from Google Cloud inspires us to push the boundaries even further!”

The Future is Cloud & AI, and Shivaami is Leading the Way!
With businesses racing towards digital transformation, Shivaami continues to be a go-to partner for companies looking to unlock the full potential of Google Cloud & Gemini.

Discover how Shivaami can transform your business: www.shivaami.com

Join the celebration! Share this exciting news and tag us using #Shivaami #GoogleCloudPartner #CloudTransformation

For media inquiries, partnerships, or consultations, reach out to:
 info@shivaami.com |  +91 775 784 1333

Gataca Labs Unveils A New Line of Performance and Longevity Supplements in India

Gataca Labs Unveils A New Line of Performance and Longevity Supplements in India

Hyderabad, India – March 2025 — Gataca, a wellness and nutraceutical company, has officially launched its cutting-edge line of performance and longevity supplements in India. Designed for those who aspire to live longer, perform better, and age smarter, these supplements are backed by the latest scientific research and developed using the highest quality ingredients.

Live Longer Through Peak Performance – Gataca aims to empower individuals by targeting some of the most critical factors associated with aging and vitality. Each of the five meticulously formulated supplements is designed to:

  • Boost peak physical and mental performance
  • Slow down biological aging
  • Improve overall health and wellness
  • Enhance energy & endurance

Product Highlights

Gataca’s lineup includes five high-performance supplements, each crafted to support key cellular processes and reduce inflammation—the cornerstone of many aging-related conditions.

  1. NMN (Nicotinamide Mononucleotide)

As the brand’s flagship product, the NMN supplement serves as a direct precursor to NAD+, the critical molecule responsible for cellular energy production. With 99+% pure β-NMN, Gataca offers NMN in three dosage variants: 250mg, 500mg, and 1000mg, making it among the most potent options available for daily supplementation.

  1. Trans-Resveratrol

Derived from Japanese Knotweed, this potent polyphenol is known for its powerful anti-inflammatory and antioxidant benefits. With 99+% purity, Gataca offers 250mg and 500mg doses, providing the best-in-class resveratrol supplement in India.

  1. Ca-AKG (Calcium Alpha-Ketoglutarate)

A stable, bioavailable form of AKG that plays a crucial role in cellular energy metabolism, protein synthesis, and overall vitality. Gataca’s Ca-AKG is optimized for maximum absorption and efficacy.

  1. TMG (TriMethylGlycine)

A methylated form of glycine that aids DNA repair, supports methylation pathways, and regulates homocysteine levels—a marker of cardiovascular and aging-related health. Gataca’s TMG offers 99+% purity for optimal support.

  1. Apigenin

A plant-based flavonoid that complements NMN by inhibiting CD38, an enzyme that depletes NAD+ levels, while also helping to reduce chronic inflammation. Additionally, Apigenin helps people fall asleep and stay asleep.

Transparency and Education First

All Gataca products undergo rigorous third-party testing to ensure unmatched purity and performance. Committed to transparency and science-backed wellness, the company also focuses on educating consumers with accurate, accessible information to support informed health decisions.

Where to Buy

Gataca products are now available on major e-commerce platforms like Amazon and Flipkart, as well as through the brand’s official website www.gataca.in. Customers can benefit from exclusive promotions, free shipping, and a 30-day money-back guarantee.

About Gataca

Gataca is a health and wellness company dedicated to supporting healthy aging and peak human performance. By offering top-tier, scientifically validated supplements, Gataca empowers individuals to live longer though peak performance

Media Contact:
Email: info@gataca.in
Phone: +91 83410 24757
Website: https://gataca.in

Disclaimer: The publisher does not guarantee the claims made in this article. For product-related queries, please contact Gataca directly.

Indian Analyst Manish Bhardwaj (Delhi Wale Guruji) Forex Indian technical analyst with 17 years of experience. Sells Cutting-Edge Trading Robot for ₹10 Crore to Foreign Firm

Indian Analyst Manish Bhardwaj (Delhi Wale Guruji) Forex Indian technical analyst with 17 years of experience. Sells Cutting-Edge Trading Robot for ₹10 Crore to Foreign Firm

April 7, 2025 – In a groundbreaking deal, renowned Indian trader Manish Bhardwaj, Forex Indian technical analyst with 17 years of experience popularly known as Delhi Wale Guruji (DWG), has successfully sold his advanced analysis robot to a foreign company for ₹10 crore. Developed under his firm, DWG Algo Training, the AI-powered system has earned widespread recognition for its precise market analysis and highly accurate signals.

The analysis robot, designed with cutting-edge algorithms and AI-driven technology, provided real-time insights to traders, helping them make consistently profitable decisions. Its ability to analyze complex market trends with remarkable accuracy made it a game-changer in algorithmic trading.

The foreign company, whose name remains undisclosed due to contractual agreements, recognized the robot’s potential to revolutionize trading strategies. After extensive negotiations, the deal was finalized, marking a significant milestone for Manish Bhardwaj and further solidifying India’s growing influence in the global fintech and algorithmic trading sector.

“This trading robot was created after years of expertise, rigorous testing, and real-market applications. It has helped traders maximize profits while minimizing risks. Selling it to an international firm is a proud achievement and a step toward global expansion,” said Manish Bhardwaj (Delhi Wale Guruji), founder of DWG Algo Training.

This multi-crore deal highlights the increasing global demand for AI-driven financial technology and reaffirms India’s position as a leader in fintech innovation. As algorithmic trading continues to evolve, the success of DWG’s trading robot signals a major shift toward AI-powered decision-making in financial markets.

SportingBites: Where Passion Meets Precision in Worldwide Sports

SportingBites: Where Passion Meets Precision in Worldwide Sports

Sports websites are in abundance as the digital world grows. Several pages and websites share multiple information, covering as many aspects of sports as possible. Amidst this race of climbing the ranks and being number one, SportingBites does the same thing with a slight difference. Something that sets it apart from the others.

If you try to search for a specific country’s game, you’ll find two options: a page dedicated to a specific sport and a page that’s going for all of it. It takes time and effort to scower through one-for-all websites if they are not organized. These options make you jump from one page to another or open several tabs.

SportingBites specifically targets the USA sports department. As with every other site, it’s in a continuously growing and developing phase. Regardless of that, the staff provides any and every information they can regarding US sports.

Primary Focus

Mainly, it’s considered that the USA has a few sports like rugby (American football), soccer, and basketball. If you dive deep, you’ll find many more sports on multiple levels. Even the most basic games are hyped from high school to national level games.

We at SportingBites multi-task when it comes to USA-based sports. We uncover many other sports and several intra-level competitions while also providing information to the public that needs it.

For example, we all know the craze for the NBA in America. The country also consists of a platform and a sport called college basketball. It sounds simple, but it has a huge following, including major universities clashing to win the titles. It also acts as a recruitment tool for age groups of the National teams and major NBA teams.

Imagine this same scenario in every widely followed and upcoming sport played in America. It’s almost endless. Now, consider a group of people that push themselves to cover this almost endless area. That’s SportingBites for you.

We try to stay up-to-date on all the American sports that people follow and admire. Imparting every piece of knowledge and information that we receive to the people as soon as possible. If you’re a fan and keep up with all these sports through any means, then the search ends here.

SportingBites is a haven for American sports. It includes and will continue to add each and every sport and competition. This may be a short note, but we also provide relevant information on the players, their plans, rankings and net worth. Basically, we provide answers to FAQs through our blogs in a detailed and simple manner to eliminate any doubts regarding the sport and the athletes.

Additional Aspects

American sports are the primary focus of SportingBites. However, we also cover other additional and prestigious sports. By covering sports, we are implying anything remotely related to sports. It includes the net worth of the players, the owner of the team, controversies, feuds, or partnerships.

Our current focus, apart from the primary aim, has been about covering the ongoing cricket league in India. Yes, you guessed it right: the Indian Premier League (IPL) 2025. We have been researching and writing the net worth of the players and their multiple income sources, including their salaries.

You can find previews of the upcoming games, the prediction of the game and the fantasy teams. Any information that an audience or a fan wants is covered in one of the many topics.

Gradually, our focus is reaching out to Football. College football falls in the American sports; We are also shifting to the other games and leagues of football, focusing on teams, and planning to collect data to provide information.

We have recently started expanding our reach to badminton, tennis, and golf. These games have their own organizations doing tours across the world throughout the year. It’s almost like a roller coaster ride of tournaments, one after another.

Anything new, exciting or noteworthy that happens in the sports world, we are already all over it. Whether it’s regarding a player or a new sport. You could say that we are trying to keep up with the trends of the sports world.

हरिद्वार में दिव्यता और भव्यता के साथ संपन्न हुआ योग योगेश्वर महाप्रभु श्री रामलाल जी भगवान का शुभ जन्मोत्सव

हरिद्वार में दिव्यता और भव्यता के साथ संपन्न हुआ योग योगेश्वर महाप्रभु श्री रामलाल जी भगवान का शुभ जन्मोत्सव

स्थान: हर की पौड़ी, नियर क्लॉक टावर, हरिद्वार, 6 अप्रैल – योग और सनातन धर्म की पुनः प्रतिष्ठा हेतु इस धरती पर अवतरित योग योगेश्वर महाप्रभु श्री रामलाल जी भगवान के शुभ जन्मोत्सव का दिव्य आयोजन आज हरिद्वार के पावन तीर्थ हर की पौड़ी (नियर क्लॉक टावर) पर अत्यंत श्रद्धा, उल्लास और दिव्यता के साथ संपन्न हुआ।

इस ऐतिहासिक आयोजन का नेतृत्व परम पूज्य स्वामी अमित देव जी महाराज के पावन मार्गदर्शन में श्री योग अभ्यास आश्रम ट्रस्ट द्वारा किया गया। देशभर के विभिन्न शहरों—विजयवाड़ा, जगाधरी, यमुनानगर, अंबाला, करनाल, पानीपत, रोहतक, दिल्ली, सोनीपत—से हज़ारों श्रद्धालुओं ने इस आयोजन में भाग लेकर आध्यात्मिक ऊर्जा एवं भावप्रवण वातावरण का अनुभव किया।

प्रमुख अनुष्ठान एवं कार्यक्रम:

महामंत्रोच्चार के साथ पावन दिवस का आरंभ

गंगाजल अभिषेक एवं श्री विग्रह का आकर्षक श्रृंगार

वैदिक हवन, कलश पूजन, एवं सैकड़ों भक्तों की सहभागिता

आरती, संकीर्तन, एवं ध्यान योग से वातावरण हुआ पूर्णतः दिव्य

श्रद्धालुओं को प्रेमपूर्वक महाप्रसाद वितरण

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आयोजन की सफलता में मुख्य कार्यकारी मंडल की भूमिका

इस भव्य आयोजन को साकार करने में जिन समर्पित सेवकों की विशेष भूमिका रही, वह “मुख्य कार्यकारी मंडल” निम्नलिखित है:

श्री महेश चंद गोयल जी

श्री राजेंद्र बजाज जी

श्री रवि भूषण चावला जी

श्री अंकुश ओहरी जी

श्री राजीव तनेजा जी – जिन्होंने अपने भावपूर्ण भजनों से श्रद्धालुओं को भावविभोर किया

आचार्य रजनीश जी

योगाचार्य मंगेश त्रिवेदी जी

योगाचार्य विनय भाटिया जी

इन सभी ने अद्वितीय समर्पण, संगठनात्मक कौशल एवं प्रेमपूर्ण सेवा से आयोजन को दिव्यता, भव्यता और गरिमा प्रदान की।

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गुरुदेव के प्रशिक्षित योग शिक्षक, विद्यार्थी एवं संगी स्तुतिकर्ता

गुरुदेव के प्रशिक्षित योग शिक्षकों एवं विद्यार्थियों—योगाचार्य शशिकांत शाक्य, लक्ष्मी गिरी, कोमल, मीनाक्षी, दीपा, नितिका, मानवी और यश—ने अपनी योग प्रस्तुतियों के माध्यम से जनसमूह को पूर्णतः मंत्रमुग्ध कर दिया और योग की आध्यात्मिक गरिमा का सजीव प्रदर्शन किया।

स्वामी जी के अनुज योगाचार्य नित्यानंद जी, योगाचार्य कार्तिकेय जी एवं देवेश देव ने भावपूर्ण रूप से गुरुदेव के संग गुरुदेव की स्तुति प्रस्तुत कर सभी श्रद्धालुओं को गहराई से भावविभोर किया।

इन सभी ने प्रशासन और श्री गंगा महासभा के सहयोग से आयोजन को सुरक्षित, शांतिपूर्ण एवं संगठित रूप प्रदान किया।

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दिव्य भविष्यवाणी की स्मृति

इस शुभ अवसर पर महर्षि काकभुशुंडी जी की वह दिव्य भविष्यवाणी भी स्मरण कराई गई जिसमें उन्होंने काकनदी तट पर कहा था:
“एक दिव्य योगावतार इस धरती पर जन्म लेगा, जो धर्म की पुनर्स्थापना करेगा, योग को जन-जन तक पहुँचाएगा और विश्व में संतुलन व शांति का मार्ग प्रशस्त करेगा।” श्रद्धालु इस भविष्यवाणी की पूर्णता महाप्रभु श्री रामलाल जी भगवान के रूप में देखते हैं।

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हर की पौड़ी का आध्यात्मिक महत्त्व

हर की पौड़ी, जहाँ माँ गंगा स्वयं प्रकट हुईं, इस आयोजन का साक्षी बनकर एक युगांतकारी आध्यात्मिक घटना का केंद्र बनी। यह आयोजन सनातन संस्कृति की जीवंत परंपरा और भारत की आध्यात्मिक चेतना की अमिट छाप बनकर उभरा।

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संयोजक:
महेश चंद गोयल – ‪+91 9811150849‬
राजेंद्र बजाज – ‪+91 9812084753‬

आयोजक संस्था:
श्री योग अभ्यास आश्रम ट्रस्ट
वेबसाइट: www.syaat.org | www.yog.guru

Abhee Ventures Sets New Record with Rs500 Crore Sales of Abhee Aaria Apartments in Just 24 Hours

Abhee Ventures Sets New Record with Rs500 Crore Sales of Abhee Aaria Apartments in Just 24 Hours

In a remarkable achievement, Abhee Ventures has made a historic mark in Bangalore’s residential real estate market by selling luxury apartments worth Rs500 crore within just 24 hours of launching Abhee Aaria in Gunjur.

Located opposite the serene Gunjur Lake along the Sarjapur-Whitefield Road, Abhee Aaria stands as one of the most prestigious high-rise developments by Abhee Ventures in Bangalore. Spanning across 12 acres of lake-facing land, the project boasts of five towers of 32 stories with over 70 lifestyle amenities and an expansive 60,000 square feet of club facilities.

“We received over 700 applications for this project, and the journey began nearly six months ago. A significant portion of the buyers are young families seeking spacious homes within a green, community-centric environment,” shared Nagaraj Reddy, Managing Director of Abhee Ventures.

Abhee Aaria’s strategic location has played a vital role in its success. The development sits within a thriving hub, surrounded by more than five international schools within 2 Km radius. With the Peripheral Ring Road (PRR) cutting across just 500 meters away, residents will have seamless connectivity to the upcoming metro line on Sarjapur Road which would be just 10 mins drive. Additionally, the project enjoys direct access to the 320-ft wide IRR road, enhancing connectivity to the Outer Ring Road (ORR), Whitefield, Sarjapur Road and the e-city office hubs, making it one of the most sought-after locations in East Bangalore.

The upcoming 1000-acre SWIFT City, a new IT hub near Sarjapur, will further elevate the area’s appeal, positioning it as a prime destination for working professionals. This large development will be just 3.5 Km from Abhee Aaria.

Designed with a focus on holistic living, Abhee Aaria features a unique “breathe-friendly” architecture, including a two-acre Central Forest, elevated walkways, a pet park, a heated swimming pool, and two massive clubhouses. With 85% open spaces across five 32-storey towers, it provides a luxurious and sustainable lifestyle. Development comes with 1,2 and large 3 Bed residences which are 3 sides open for best breathing experience.

“Our vision with Abhee Aaria is to create an integrated ecosystem of luxury residences, surrounded by nature. The overwhelming pre-launch response has inspired us to open up new inventory for buyers seeking homes that offer both comfort and an enriching lifestyle,” said Nagaraj Reddy, Managing Director of Abhee Ventures.

Having delivered over 16 successful projects in recent years, Abhee Ventures is now poised to redefine the Bangalore skyline with new landmark developments.

Implica Global Enters $259.2B Asia-Pacific Spirits Market with $250M Investment

Implica Global Enters $259.2B Asia-Pacific Spirits Market with $250M Investment

Implica Global Corporation, a European-based global technology and strategy consulting consortium, has officially announced its strategic entry into the premium spirits and wine distribution sector. The company is entering the rapidly growing Asia-Pacific market, valued at approximately USD 259.2 billion, demonstrating its ambitious global strategy. This move signifies the group’s commitment to further diversify and scale its operations, aiming to achieve a valuation exceeding $20 billion by 2030 in the premium consumer goods market.

Implica Global plans an initial investment of $250 million specifically targeting its expansion in Asia and Europe, focusing on globally unique, ultra-premium spirits and wines, rare formulas, and locally and culturally renowned selections designed for the international market.

In light of current discussions surrounding the proposed Free Trade Agreement (FTA) between the European Union and India, Implica Global is closely monitoring potential regulatory shifts that could reshape the premium beverage trade. Industry observers believe the FTA would significantly reduce excise duties on European liquor imports into India, opening the door to more competitive pricing and improved market access. As a strategic first-mover, Implica Global stands to benefit from this evolving trade landscape, further reinforcing its early expansion into key Asian markets.

As part of phase one in 2025, Implica Global will open the distribution of exclusive rights and partner distribution networks across key regions including India, China, ASEAN countries, the European Union, and extended markets such as the United Kingdom and Ireland.

According to IWSR, the demand for premium spirits in Asia is projected to grow 12% YoY through 2027.

Under the visionary guidance of CEO Sarved Dhar Badgayan, Implica Global continues to demonstrate aggressive growth and strategic foresight across various sectors.

“At Implica, we believe true luxury lies in provenance, story, and intention. Through our Global 30 vision, we are carefully curating rare spirits and culturally rich wines not just to distribute but to elevate. This is not simply about market presence; it is about crafting a global legacy with timeless brands that speak to taste, heritage, and elegance. We are here to bring the world something unforgettable.”- Sarved Dhar Badgayan, CEO and Executive Chairman, Implica Global Corporation

In addition to its expansion into premium consumer goods, Implica Global continues to support global Fortune 500 companies in supply chain management and logistics through its dedicated technology arm, ImplicaT Digital. The tech division provides advanced digital solutions and integrated services that optimize operations and streamline global logistics frameworks.

Meanwhile, Implica Consulting focuses on strategic brand building and market expansion, working closely with emerging and established companies to craft impactful narratives, enhance market positioning, and accelerate international growth.

The corporation plans to leverage its established global network and advanced analytical capabilities to deliver artisanal and luxury spirits and wine collections to international markets. Positioned in over 25 countries, Implica Global’s entry into the spirits and wine consulting and distribution industry underscores its goal of becoming a major global player in consumer goods.

Currently, the group is evaluating high-potential spirits and wine brands and has committed to launching this venture under a distinct, yet-to-be-disclosed brand name, separate from Implica, which will remain dedicated exclusively to technology, strategy consulting, and capital ventures. The forthcoming premium beverage brand will be overseen by the London division of the holding company, aligning with the group’s structured approach to sector diversification and growth.

Details regarding the brand and trading name will be disclosed at a later stage, underscoring Implica Global’s meticulous approach to launching impactful, high-value ventures.

Website – https://www.implicaglobal.com.

A Groundbreaking Celebration of Music, Culture, and Art Set to Redefine Live Entertainment

A Groundbreaking Celebration of Music, Culture, and Art Set to Redefine Live Entertainment

The stage is set for an extraordinary musical journey as one of the most ambitious concert series of the decade prepares to launch. This landmark event promises to bring together global icons, emerging talents, and an audience that truly appreciates the power of music and culture.

With an aim to revolutionize live entertainment, this series will not just be about performances but about curating an unforgettable experience. From immersive stage designs and world-class production to interactive audience engagements, the event is poised to set new benchmarks in the industry.

Kicking off in September 2026, the series will span multiple cities, including Delhi, Chandigarh, Mumbai, Bangalore, Kolkata, and even an international showcase in Dubai. Each city will witness a unique interpretation of music, art, and storytelling, blending traditional elements with modern innovations.

Speaking about the vision behind this grand endeavor, Om Dogra, Project Co-Chair, Rhythm Odyssey said, “Music is not just an art form; it’s an emotion, a language that unites us all. This concert series is more than just a set of performances–it’s a movement to celebrate the power of sound, culture, and connection on a scale never seen before.”

The event’s vision extends beyond music, incorporating a deeper cultural impact. By fostering artistic collaborations and providing a platform for young talent, it aims to bridge generations of music lovers. Moreover, a segment of the initiative is dedicated to giving back, with special programs supporting music education and sustainable event practices.

With an estimated audience reach in the millions, this series is not just an event–it’s a movement. It’s about creating moments that will be remembered for years, elevating the standard of live entertainment, and celebrating music in its purest form.

Stay tuned for more updates as we unveil the next chapter of this musical revolution.

Groundbreaking Study Reveals Evolutionary Origins of Sleep in Single-Celled Algae

Groundbreaking Study Reveals Evolutionary Origins of Sleep in Single-Celled Algae

Cross-Kingdom Conservation of Sleep-Related Genes in Chlamydomonas Sheds Light on Fundamental Biological Process

Mysuru, Karnataka, 3 April 2025 — A groundbreaking study published in the Journal of Cellular Biochemistry has uncovered compelling evidence that sleep, a behavior once thought to be exclusive to complex organisms, may have its roots in the simplest forms of life. The research, led by an international team of scientists, identifies 112 putative sleep-related genes in the single-celled green alga Chlamydomonas reinhardtii, suggesting that the molecular mechanisms regulating sleep have been conserved across kingdoms for over 500 million years.

Key Findings:

  • Evolutionary Conservation: The study reveals that sleep-related genes in humans share significant similarities with those in Chlamydomonas, highlighting an evolutionary continuum from unicellular organisms to mammals.
  • Novel Discoveries: Among the identified genes are previously uncharacterized proteins, such as CHLRE_16g686650v5, which exhibit high sequence similarity to human sleep genes, opening new avenues for understanding sleep regulation.
  • Functional Insights: Well-known proteins like casein kinase I (CKI) and voltage-dependent calcium channels, critical for circadian rhythms and signaling in humans, were also found in Chlamydomonas, reinforcing their pleiotropic functions.

Implications for Science and Medicine:

This research challenges traditional views of sleep as a purely neural phenomenon, proposing instead that its origins lie in fundamental cellular processes. “Our findings suggest that sleep’s essential functions—energy conservation, cellular repair, and adaptation—may have evolved early in life’s history,” said Pandi-Perumal, one of the study’s lead authors. “Our current findings related to putative sleep genes in Chlamydomonas, a flagellated autotrophic plankton, could revolutionize how we view the evolution of human sleep genes, which eventually helps to study sleep disorders and develop potential therapies by targeting conserved pathways.”

Why It Matters:

  • Model Organism: Chlamydomonas, a simple alga with a well-mapped genome, offers a powerful tool for dissecting sleep mechanisms without the complexity of animal models.
  • Future Research: The study paves the way for exploring how these putative sleep genes in single-celled organisms contribute to survival, with potential applications in neurology, chronobiology, and even synthetic biology.

Expert Commentary:

“If sleep orthologs exist in algae, it forces us to rethink its purpose,” noted Dr. Chidambaram, co-corresponding author and a professor at the Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. “This work bridges the gap between microbiology and neuroscience, offering a unified framework to decode sleep’s mysteries through phylogenomics.”

According to Dr. Saravanan, one of the co-authors and Bioinformatics expert, “This study presents an interesting computational framework that enhances cross-genomics comparison by integrating multiple phylogenomic analysis of sleep genes such as Gene ontology, Interpro sites analysis, Repeats analysis and Pathway analysis, offering significant improvements in accuracy, efficiency, and analytical depth.”

According to Prof. Abraham, a Former Professor & Head of the Post-Graduate Department of Botany, at The American College, Madurai, who is one of the co-authors of the study said, “This is an exemplary work, even though we say it ourselves. This phylogenomics study unveils unprecedented insights into evolutionary and functional parallels between putative sleep genes of Chlamydomonas and human sleep genes.”

Overall, the results of this study present an interesting and in-depth analysis of Cross-Kingdom Genomic Conservation of Putative Human Sleep-Related Genes in Chlamydomonas, uncovering previously unreported evolutionary and functional parallels, particularly in protein kinase domains involved in the information storage and processing, providing new insights into conserved genetic elements and their implications in cellular processes.

Publication Details:

The full study, “Cross-Kingdom Genomic Conservation of Putative Human Sleep-Related Genes: Phylogenomic Evidence From Chlamydomonas reinhardtii,” is available in the Journal of Cellular Biochemistry (2025; DOI: [https://doi.org/10.1002/jcb.70030]).

For Media Inquiries:

Contact: Lemuria Global Network
Email: lemuriaglobal@gmail.com

About the Journal of Cellular Biochemistry:

A peer-reviewed publication by Wiley, the journal advances research on cellular mechanisms underpinning health and disease. https://onlinelibrary.wiley.com/doi/full/10.1002/jcb.70030

How to cite this paper:

Pandi-Perumal SR, Saravanan KM, Paul S, Abraham GC, Warren Spence D, Chidambaram SB. Cross-Kingdom Genomic Conservation of Human Sleep-Related Gene Orthologs: Phylogenomic Evidence from Chlamydomonas reinhardtii. J Cellular Biochem. https://doi.org/10.1002/jcb.70030 (First published: 31 March 2025).